Dr. Wang received his bachelor degree from Nanjing Agricultural University, his master degree and Ph.D. degree from Xiamen University in China. In 1999, He went to Singapore joined the Institute of Molecular and Cell Biology as a Research Fellow, In 2007, he was recruited toXiamen University as Professor of the school of pharmaceutical sciences.
The membrane trafficking (or protein transport) pathway includes exocytosis and endocytosis. The proteins synthesized on ribosomes associated with the endoplasmic reticulum (ER) are transported via vesicle from ER to the Golgi apparatus, then secreted out of the cell, or transported from the Golgi apparatus to the endosome and lysosome for degradation. At the same time, cells take-up nutrients via endocytosis, by which materials are internalized from cell surface and transported to the endosome and lysosome or the Golgi apparatus. The receptor-mediated endocytosis is also closely related to cellular signal transduction, and this process regulates cell growth, proliferation, and death. Many pathogens like viruses, bacteria invade cell also via endocytic or phagocytic pathways.
Our lab’s researches focus on investigating the cellular and molecular mechanisms governing membrane traffic in the secretory and endocytic pathways and the roles of membrane trafficking in diseases, exploiting the novel drug targets and biomarkers for diseases from membrane traffic machineries.
Selected Publications:（last 5 years）
Wang T*, Zhang M, Ma Z, Guo K, Tergaonkar V, Zeng Q, Hong W*. A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. J Cell Physiol. 227(6):2788-97， 2012 (*corresponding authors)
Wang T, Ming Z, Xiaochun W, Hong W. Rab7: role of its protein interaction cascades in endo-lysosomal traffic. Cell Signal. 23(3):516-21， 2011
Wang T, Liu NS, Seet LF, Hong W. The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking. Traffic. 11(9):1119-28，2010
LiChen, Jingjie Hu, Ye Yun and Tuanlao Wang*. Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. Mol. Mem.Biol. 27（1）：24-31，2010 (*corresponding author)
Zhang M, Chen L, Wang S, Wang T*. Rab7: Roles in Membrane Traffic and Disease. Biosicence Report. 29(3):193-209，2009 (*corresponding author)